hrp0086p1-p458 | Fat Metabolism and Obesity P1 | ESPE2016

Association of miR-34a and mir-149 with Obesity and Insulin Resistance in Obese Children and Adolescents

Nourbakhsh Mitra , Ahmadpour Fatemeh , Khaghani Shahnaz , Alipour Behnam , Razzaghy Azar Maryam

Background: Obesity is a major public health problem and its rate is increasing worldwide. Obesity accompanies perturbations in metabolism, conferring substantial excess risk for insulin resistance and Type 2 diabetes. Various genetic and epigenetic factors contribute to the development of obesity. MicroRNAs (miRNAs) are short noncoding RNAs involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipid metabolis...